Pediatric Precision Cancer Medicine Program

Advanced testing helps us deliver precise diagnoses, personalized treatments and better outcomes.
Pediatric Precision Cancer Medicine Program

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Why choose UCSF Benioff Children's Hospitals for personalized cancer care?

At UCSF Benioff Children's Hospitals, we are leading the way in precision cancer care by tailoring treatment to each child. Cancers can differ in important genetic and molecular ways.

State-of-the-art testing allows us to uncover these key differences so we can make more accurate diagnoses and select the most effective therapies. Through our clinical trials, children have access to promising new treatments before they're widely available.

Genomic testing with UCSF500

The UCSF500 cancer gene panel is a sophisticated tool that analyzes both DNA and RNA to understand a tumor's molecular characteristics. It evaluates approximately 500 cancer-related genes, looking for changes (mutations) that could affect how the cancer behaves and responds to treatment.

The UCSF500 panel is part of routine care at UCSF, so every child we treat benefits from this advanced test. It helps us:

  • Confirm or refine a diagnosis

  • Detect changes, such as gene fusions, which are especially common in pediatric cancers

  • Identify new treatment opportunities for cancers that have relapsed or are resistant to treatment

  • Select treatments that are more likely to be effective

Opportunities for personalized therapies

We draw on molecular findings and our clinical expertise to better tailor treatment to each child. Testing can help us:

  • Better understand and predict how cancer might behave

  • Detect biomarkers that make a child eligible for a clinical trial

  • Determine whether we can safely increase or decrease the intensity of treatment

  • Discover gene alterations that can be targeted with specific therapies

Understanding inherited cancer risk

Another way we personalize care is through germline testing, which helps identify a child's inherited cancer risk. Germline testing analyzes DNA in normal cells, rather than tumor cells. It looks for genetic changes present at birth.

This information can help us understand a child's cancer risk and, in some cases, inform treatment or follow-up recommendations. Our pediatric hereditary cancer program provides comprehensive genetic testing, genetic counseling and guidance to support the whole family.

Highlights of our cancer care

  • Leading-edge treatments

    We're among the first to offer new treatment options, as soon as they're proven safe and effective. In addition, patients can access promising experimental therapies by participating in one of our many clinical trials.
  • Precision medicine

    High-risk tumors are analyzed with the UCSF500 Cancer Gene Panel, a state-of-the-art test that identifies mutations in the tumor's DNA. The results can indicate the best treatment course and, in some cases, clarify the exact type of cancer.
  • Seamless care, near and far

    Dedicated patient navigators help families with managing referrals, insurance concerns and appointment planning. We work with patients and referring doctors well beyond the San Francisco Bay Area, thanks to our comprehensive telehealth system.
  • Thorough follow-up

    Our Pediatric Survivorship Program provides expert care to address any medical, psychological or social issues that arise after treatment is complete. The team also ensures smooth transitions to adult care providers as our patients leave childhood behind.

Providers

Awards & achievements

Recognized nationally for excellence, we pair world-class medical expertise with compassionate care to deliver the best possible outcomes for patients.
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  • U.S. News & World Report Best Children's Hospitals 2026-2027, cancer

    Best in Northern California and top 10 in the nation for cancer care

  • Designated an early phase clinical trials core site by the Children's Oncology Group

  • U.S. News & World Report Best Children's Hospitals 2026-2027, ranked in 11 specialties

    Ranked among the nation's best in 11 specialties

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Related conditions & treatments

  • Conditions
  • Treatments
    • Clinical Trials
    • Genetic Cancer Risk Assessment
    • Genetic Counseling
    • Genetic Testing
    • Genomics
    • Targeted Molecular Therapy
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Trials & research

Research initiatives

Resources for physicians

Whether you're referring a patient, seeking a second opinion or looking for professional education opportunities, you'll find resources on the UCSF Pediatric Cancer Program's MedConnection hub. We look forward to partnering with you!

Cancer care for adults

When the time is right, we guide young adults to the next phase of cancer care to support their long-term health.