Pediatric Eosinophilic Gastrointestinal Disease (EGID) Care

We offer comprehensive care for EGID, including minimally invasive diagnostic tests and tailored treatment plans.
Pediatric Eosinophilic Gastrointestinal Disease (EGID) Care

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Why choose UCSF Benioff Children's Hospitals for eosinophilic gastrointestinal disease (EGID) care?

Our pediatric gastroenterologists have extensive experience in diagnosing and treating all types of eosinophilic gastrointestinal disease (EGID), including the most common, eosinophilic esophagitis (EoE). We work closely with UCSF's allergy specialists to provide coordinated care, from diagnosis to long-term management.

When possible, we use minimally invasive testing to reduce stress on your child. Our EGID program is one of the few in the U.S. to offer transnasal endoscopy to diagnose EoE. We also use an esophageal string test to monitor older children with EoE. These quick and convenient in-office procedures do not require anesthesia, which means less preparation and stress on your child. Afterward, they can return to their regular activities.

UCSF's program was one of the first in Northern California to provide specialized care for EGID. U.S. News & World Report consistently ranks us among the top hospitals in the nation for gastroenterology and GI surgery.

Many families travel to UCSF to see our providers, recognized leaders in pediatric EGID care. We offer accommodations for traveling families, including coordinated, multispecialty appointments and virtual care options.

Comprehensive EGID care for children

Eosinophilic diseases develop when high levels of eosinophils (a type of white blood cell) build up in one or multiple parts of the digestive system, causing swallowing and eating problems.

We treat all types of EGIDs, including in the:

  • Esophagus (eosinophilic esophagitis)

  • Stomach and small intestine (eosinophilic gastritis, eosinophilic gastroenteritis and eosinophilic enteritis)

  • Large intestine (eosinophilic colitis)

Our EGID program offers the combined experience of several pediatric specialists. Your child's care team may include:

  • Gastroenterologists

  • Allergists

  • Dietitians

  • Social workers

Eosinophilic gastrointestinal disease testing

Your first visit with us lasts about two hours. We review your child's medical history and perform a physical exam. We may recommend testing to help us confirm a diagnosis and identify which foods may be triggering their symptoms. Tests may include:

Transnasal endoscopy

Transnasal endoscopy is an anesthesia-free alternative to traditional endoscopy that's used to diagnose EoE. Before the procedure, we numb the inside of your child's nose and mouth with a topical anesthetic to keep them comfortable.

We gently insert a thin, flexible camera through the nose to examine your child's esophagus, stomach and small intestine. Your child may use our virtual reality (VR) goggles during the endoscopy as a helpful distraction.

EGID treatments

We work with you to find the right therapies, helping your child manage symptoms and feel their best. Depending on their diagnosis and symptoms, we may recommend a combination of several therapies, including:

  • Dietary changes

  • Oral medications

  • Biologics (injectable medications)

Follow-up and monitoring

We provide ongoing care and follow-up visits to monitor eosinophilic gastrointestinal disease. We track your child's symptoms, growth and response to treatment over time.

If your child is trying a new medication or has a symptom flare-up, we may recommend an endoscopy or other testing to help us adjust their care plan.

Esophageal string test for EoE

We may use an esophageal string test to monitor older children with EoE. The in-office test doesn't require anesthesia or recovery time.

Here's what to expect during an esophageal string test:

  1. Your child swallows a small capsule attached to a string. The other end of the string is taped to their cheek or finger.

  2. The capsule dissolves, while the string absorbs esophageal secretions for one hour.

  3. Your child's provider gently pulls the string out through the mouth.

  4. The string is sent to the lab, where we measure the absorbed secretions to monitor for inflammation in the esophagus.

Results from the esophageal string test help us tailor your child's treatment plan and measure changes in EoE.

Providers

Awards & achievements

Recognized nationally for excellence, we pair world-class medical expertise with compassionate care to deliver the best possible outcomes for patients.
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  • U.S. News & World Report Best Children's Hospitals 2026-2027, gastroenterology and GI surgery

    Best in Northern California and top 10 in the nation for gastroenterology & GI surgery

  • U.S. News & World Report Best Children's Hospitals 2026-2027, ranked in 11 specialties

    Ranked among the nation's best in 11 specialties

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Related conditions & treatments

  • Conditions
    • Eosinophilic Colitis
    • Eosinophilic Enteritis
    • Eosinophilic Esophagitis
    • Eosinophilic Gastritis
  • Treatments
    • Allergy Testing
    • Biologic Therapy for Gastrointestinal Diseases
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Trials & research